Herk, I can't think of any reason myself. I would love to live there and because I already have a piece of land there I am looking forward to it. There is lots of public land there to explore. The Windriver mountains are awesome! The Green River runs through there too. So lots of out doors activities and ,in my mind, lots of area to bug out in. It gets cold and snowy but you should be use to that eh? The area is still booming with oil and gas drilling so if you have work I think you should be OK. All the towns are small and lots of rural living.
If you want to say, what part of Sublette are you looking at?